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Award: Musketeer of the Year, Quiz Whiz of the Year (2011)
Joined: Tue Dec 23, 2008 5:22 am
Posts: 19081
Location: Midway between the infinite and the infinitesimal! Award: Musketeer of the Year, Quiz Whiz of the Year (2012) |
Hi Sarah.
You don't say what type of health professional you are, but you say you have covered most of the options, and therefore presumably understand the medical and medicinal terms and appropriate information. This makes it easier.
The first recommendation for taking a young child into a malarial area is always to tell you not to. However - and no-one can make that decision but you - if you choose to, to facilitate a sage decision, it is worth remembering the following factors.
Kruger is still a relatively low-risk area in August. You also haven't told me what type of accommodation you're staying in, but if it in newer chalets, the mosquito netting most likely will still be intact (check it anyway), thereby lowering risk if you take other suitable precautions. The baby-friendly DEET spray is great to use, if she is able to.
The risk of malaria infection is from dusk until dawn, so make sure that you have her indoors then, cover her body as much as possible (it can be cold that time of the year, which assists in togging her up), and perhaps even consider letting her sleep beneath mosquito netting (just in case that stray infected mosquito bites her).
Personally, I wouldn't take such a young child into a malaria area. However, if you do, I would definitely consider chemoprophylaxis for her. You are correct that chloroquine is no longer recommended for chloroquine-resistant areas, which Kruger has become. It is not that she would get no cover at all, but the side-effects would outweigh the benefit, especially as only a low percentage of cover is now likely with the drug.
Therefore, for children, though there are several opinions on this, the drug of choice seems to be mefloquine (e.g. Lariam). It can be used from 5 kg upwards, but at the weight you anticipate your child to be at the time of visiting Kruger, it is a fine line between taking 1/8 tablet per week for a child of 5-9kg, or a 1/4 of a tablet per week from 10-19kg, as antimalarial prophylaxis. Let your doctor decide.
Atovaquone/proguanil combinations (e.g. Malorone) can be used for antimalarial prophylaxis in children too, but it is only suggested from 11kg upwards, probably because the manufacturers have insufficient information to recommend it below this weight. Malorone has paediatric tablets available, which facilitates ease of administration. Lariam tablets have to be broken and the suitable portion crushed for children.
Atovaquione/proguanil combinations have the advantage of being used for antimalarial prophylaxis from a day before entering a malarial area, and then continuously until seven days after exiting the malarial area (this is because it is the only malaria medication that targets both the liver and blood stages of malarial infection within the body). It is a daily dosage.
Mefloquine must be used from 2-3 weeks before entering the antimalarial area, every week extra spent in the area, and for 4-6 weeks after exiting the malarial area. It's dosage is weekly.
Anti-malarial tablets may be crushed and mixed with e.g. chocolate syrup, jam, cereal or bananas to mask the taste. Tablets, especially mefloquine, should be protected from sunlight and high humidity once they have been removed from the foil wrapper.
Side-effects of either medicine is both medicine-specific and sometimes patient-specific. Frequent side-effects of atovaquone/proguanil include nausea, vomiting, abdominal pain, and diarrhoea. Frequent side-effects of mefloquine include transient dizziness, diarrhoea, nausea, vivid dreams, nightmares, irritability, mood alterations, headache, and insomnia.
As you can see, there are many considerations to take into account, and you and your health professional and/or doctor will have to weigh everything up. There is also the consideration that, if a child gets malaria, the progression of the illness can become fatal quickly. In addition, children often suffer from colds and flus, and malaria symptoms often mimic these. Then there may be consequences to the side-effects of the medicines - for example, diarrhoea and vomiting van lead to rapid dehydration in children if not well managed.
Whatever decisions you aim at, good luck and I hope you make the right choices! If you do decide to come with your baby, I hope that you will have a good time and that everyone will remain well.
Hope this helps?
Regards, OWN.Disclaimer: My recommendations here - though based on some experience and some drug knowledge - are not absolute, and further consultation with suitable health-care professionals is suggested before a final decision is taken on whether to enter a malarial area, what prophylaxis to use, and any general factors and limitations that need to be taken into account. Furthermore, I only advise based on what information is given by the person(s) entering the malarial area, but I have no control on the information given to me, and so such information could possibly be incomplete or misleading.
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